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Zephyrhills Business Climate

A Downtown Rich in Character

Drive through historic downtown Zephyrhills on any day and you’ll quickly understand the town’s charm. Neighbors of all ages gather to chat along sidewalks outside locally owned shops, restaurants, and cafés. On weekends, the streets come alive with family-friendly festivals and community events that draw residents and visitors alike.

A Corridor of Commerce

Heading north along Gall Boulevard (U.S. 301), the city’s main artery, you’ll pass dozens of thriving businesses. Florida Medical Clinic and AdventHealth Zephyrhills anchor the corridor with state-of-the-art healthcare campuses, while both sides of the boulevard feature modern shopping plazas filled with a healthy mix of national retailers and bustling local enterprises.

Strategic Location and Connectivity

Zephyrhills is uniquely positioned at the crossroads of major transportation networks. Interstate 75, Interstate 275, Interstate 4, and U.S. 301 connect the city to Tampa Bay and Central Florida. The CSX Railroad runs just east of town, and the Port of Tampa—Florida’s largest port—is only 45 minutes away. This strategic access supports efficient logistics for manufacturers, distributors, and e-commerce fulfillment centers.
With Tampa, Orlando, international airports, world-class theme parks, and Gulf Coast beaches all within an hour’s drive, Zephyrhills offers both convenience and connectivity.

Industry and Innovation

Zephyrhills’ industrial corridor continues to attract new, expanding, and relocating businesses. One of the city’s signature success stories is Zephyrhills® Natural Spring Water, now operated by Primo Brands (formerly BlueTriton Brands). The bottling plant remains a major employer and a global brand ambassador for the community, highlighting Zephyrhills as a source of premium natural spring water.

Beyond water bottling, the city supports a diverse economy that includes food processing, logistics, manufacturing, and small-business startups. Local companies benefit from the city’s infrastructure, with CSX rail lines just 15 minutes south on U.S. Highway 39 offering a direct connection to the Port of Tampa.

A Climate for Growth

Zephyrhills’ blend of historic character, modern healthcare, strong infrastructure, and strategic location makes it a magnet for both homegrown innovation and outside investment. With a mix of longstanding companies and scalable startups, the city continues to cultivate a business climate defined by opportunity, innovation, and long-term growth.

advent health dade city

Healthcare as an Economic Driver

Healthcare is one of Zephyrhills’ strongest industries. The following providers (each with more than roughly ten staff) contribute significantly to employment, patient access, and medical infrastructure:

  • AdventHealth Zephyrhills — The primary hospital in Zephyrhills, providing a wide range of inpatient, outpatient, surgical, rehabilitation, and specialty services.

  • AdventHealth Dade City — Part of the same AdventHealth network, supporting regional hospital capacity.

  • Florida Medical Clinic - Orlando Health — Zephyrhills Multi-Specialty Campus (Market Square) — Approximately 75 physicians and mid-level providers located at 38135 Market Square.

  • Florida Medical Clinic -  Orlando Health — Zephyrhills Primary & Specialty Care (Eiland Blvd) — A multispecialty campus offering primary care and specialty services to the community.

  • Palm Medical Centers — A primary/senior care clinic located at 6836 Medical View Lane.

  • Premier Community HealthCare Group (Zephyrhills location) — A Federally Qualified Health Center (FQHC) serving Pasco and Hernando counties with services including family medicine, pediatrics, women’s health, dental, behavioral health, pharmacy, podiatry, chiropractic, and more.
water plant

Zephyrhills: A Hub for Homegrown Innovation and Expanding Enterprises

Zephyrhills continues to cultivate a thriving business environment, anchored by both nationally recognized brands and innovative local startups. One standout success story is Zephyrhills® Natural Spring Water, a brand now owned by Primo Brands (formerly BlueTriton Brands). Although once operated under Nestlé Waters North America, the bottling plant remains a key economic asset in the community. It continues to employ local residents and contribute to the region’s visibility as a producer of premium natural spring water—sourced directly from the area’s aquifers.

The city's strong infrastructure further enhances its economic appeal. Products from major manufacturers and distributors are efficiently transported to the Port of Tampa via CSX rail lines, originating just 15 minutes south of Zephyrhills on U.S. Highway 39. This logistics advantage supports industries ranging from bottling and food processing to distribution and e-commerce fulfillment.

With a mix of longstanding companies, scalable startups, and strategic transportation access, Zephyrhills continues to be a magnet for economic growth, business innovation, and regional investment.

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